Order Mnemonic:

Acetylchol

Dept Name:

SEND OUTS

Reference Lab:

MICHIGAN STATE UNIVERSITY (MSU)

Refer to:

MSU Labs

Transport:

Amniotic fluid, ambient

Processing:

None

Stability After
Processing:

Ambient

Reference Range:

By report

Additional Info:

AChE is a diagnostic test employed along with amniotic fluid AFP to detect open fetal defects. AChE leaks into the amniotic fluid from an opening in the neural tube or ventral wall of pregnancies affected by open fetal defects, leading to detectable levels of AChE in the amniotic fluid. AChE testing is indicated when the amniotic fluid AFP level exceeds 2.0 MoM or when there is an increased risk for an open fetal defect due to elevated MSAFP, an abnormal ultrasound, or a family history of an open fetal defect, regardless of the amniotic fluid AFP level. An estimated 98% of open neural tube defects are detected with AFAFP and AChE testing. The detection rate for anencephaly is even higher. Gastroschisis is also associated with a very elevated amniotic fluid AFP, and the AChE is positive in over 95% of cases. Alternatively, omphalocele may result in normal or mildly elevated amniotic fluid AFP levels, while AChE is normal in over 95% of cases.

Methodology:

Polyacrylamide gel separation by electrophoresis of acetylcholinesterase (AChE) in amniotic fluid.

CPT Codes:

82013

Performed:

Varies

Reported:

Varies

NCD/LCD ABN Required:

No