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Test Name: BREAST TRIPLE STAIN (CK5 + p63 + CK 8/18)       Test #0

Order Mnemonic:

Miscellaneous Test

Dept Name:

SEND OUTS

Reference Lab:

CLARIENT

Ref. Lab Test No.:

CLTRIST

Refer to:

Clarient

Collection Requirements:

To perform IHC testing, we request formalin-fixed, paraffin-embedded tissue samples. Please ensure that the blocks are clearly labeled with the patient name or identifier, date of birth and type of sample (tumor, normal). Additionally, a copy of the pathology report accompanying the tissue block will be very helpful.

Transport:

Ambient. Use cold pack if temperatures are hot.

Processing:

Stability After
Processing:

Reference Range:

By Report

Additional Info:

The combination of CK5 + P63 + CK8/18 (Breast Triple Stain) can be extremely useful in distinguishing ductal carcinoma in situ (DCIS) from microinvasive breast carcinoma. This cocktail is good at deciphering between a radial scar and infiltrating carcinoma. P63 (nuclear brown) and CK5/6 (cytoplasmic brown) stains myoepithelial cells, whereas CK8/18 labels the cytoplasm (red) of all ductal or lobular epithelium.

Methodology:

IHC

CPT Codes:

-88342

Alternative Names:

 

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